2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD)
Homo sapiens — UniProt Q8TDX5
Data last refreshed: (UniProt release unknown)
Key facts
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD) is a protein from Homo sapiens identified by UniProt accession Q8TDX5, 336 residues long. MolForge cross-references it against 1 known binders and 86 disease associations.
- UniProt accession: Q8TDX5; gene symbol ACMSD.
- Organism: Homo sapiens.
- Length: 336 amino acids.
- Top disease associations (Open Targets): erythrocyte count, low density lipoprotein cholesterol measurement and body fat percentage.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
|---|---|
| UniProt accession | Q8TDX5 |
| Gene | ACMSD |
| Organism | Homo sapiens |
| Length | 336 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.44
- low density lipoprotein cholesterol measurement · score 0.41
- body fat percentage · score 0.41
- grip strength measurement · score 0.40
- red blood cell density measurement · score 0.37
- total cholesterol measurement · score 0.37
- diastolic blood pressure · score 0.36
- high density lipoprotein cholesterol measurement · score 0.36
- mean corpuscular volume · score 0.35
- sex hormone-binding globulin measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TDX5-F1 | alphafold | PREDICTED | 97.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TDX5.
Amino-acid sequence (336 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ACMSD?
The strongest Open Targets associations for ACMSD are erythrocyte count, low density lipoprotein cholesterol measurement, body fat percentage, grip strength measurement and red blood cell density measurement.
How long is the ACMSD protein?
The Homo sapiens ACMSD protein (UniProt Q8TDX5) is 336 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TDX5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TDX5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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