Actin-related protein T2 (ACTRT2)

About Actin-related protein T2

Actin-related protein T2 (ACTRT2) is a protein from Homo sapiens identified by UniProt accession Q8TDY3, 377 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Actin-related protein T2
UniProt accession	Q8TDY3
Gene	ACTRT2
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

BMI-adjusted waist-hip ratio · score 0.42
monocyte count · score 0.40
heel bone mineral density · score 0.39
bone quantitative ultrasound measurement · score 0.36
mean platelet volume · score 0.36
waist-hip ratio · score 0.32
coronary artery disease · score 0.30
bone density · score 0.30
serum gamma-glutamyl transferase measurement · score 0.30
high density lipoprotein cholesterol measurement · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TDY3-F1	alphafold	PREDICTED	93.43	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TDY3.

Amino-acid sequence (377 residues)

MFNPHALDSP AVIFDNGSGF CKAGLSGEFG PRHMVSSIVG HLKFQAPSAE ANQKKYFVGE EALYKQEALQ LHSPFERGLI TGWDDVERLW KHLFEWELGV KPSDQPLLAT EPSLNPRENR EKMAEVMFEN FGVPAFYLSD QAVLALYASA CVTGLVVDSG DAVTCTVPIF EGYSLPHAVT KLHVAGRDIT ELLMQLLLAS GHTFPCQLDK GLVDDIKKKL CYVALEPEKE LSRRPEEVLR EYKLPDGNII SLGDPLHQAP EALFVPQQLG SQSPGLSNMV SSSITKCDTD IQKILFGEIV LSGGTTLFHG LDDRLLKELE QLASKDTPIK ITAPPDRWFS TWIGASIVTS LSSFKQMWVT AADFKEFGTS VVQRRCF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards