Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1)
Homo sapiens — UniProt Q8TE68
Data last refreshed: (UniProt release unknown)
Key facts
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) is a protein from Homo sapiens identified by UniProt accession Q8TE68, 723 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q8TE68; gene symbol EPS8L1.
- Organism: Homo sapiens.
- Length: 723 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neuroinflammatory disorder and Familial exudative vitreoretinopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Epidermal growth factor receptor kinase substrate 8-like protein 1 |
|---|---|
| UniProt accession | Q8TE68 |
| Gene | EPS8L1 |
| Organism | Homo sapiens |
| Length | 723 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- neuroinflammatory disorder · score 0.32
- Familial exudative vitreoretinopathy · score 0.05
- X-linked retinal dysplasia · score 0.04
- retinitis pigmentosa and erythrocytic microcytosis · score 0.04
- severe early-childhood-onset retinal dystrophy · score 0.04
- Familial drusen · score 0.04
- hemoglobin D disease · score 0.04
- X-linked retinoschisis · score 0.04
- mean platelet volume · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TE68-F1 | alphafold | PREDICTED | 75.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TE68.
Amino-acid sequence (723 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EPS8L1?
The strongest Open Targets associations for EPS8L1 are neurodegenerative disease, neuroinflammatory disorder, Familial exudative vitreoretinopathy, X-linked retinal dysplasia and retinitis pigmentosa and erythrocytic microcytosis.
How long is the EPS8L1 protein?
The Homo sapiens EPS8L1 protein (UniProt Q8TE68) is 723 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TE68 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TE68 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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