SH3 domain and tetratricopeptide repeat-containing protein 1 (SH3TC1)
Homo sapiens — UniProt Q8TE82
Data last refreshed: (UniProt release unknown)
Key facts
SH3 domain and tetratricopeptide repeat-containing protein 1 (SH3TC1) is a protein from Homo sapiens identified by UniProt accession Q8TE82, 1336 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q8TE82; gene symbol SH3TC1.
- Organism: Homo sapiens.
- Length: 1336 amino acids.
- Top disease associations (Open Targets): aspartate aminotransferase measurement, low density lipoprotein cholesterol measurement and total cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SH3 domain and tetratricopeptide repeat-containing protein 1 |
|---|---|
| UniProt accession | Q8TE82 |
| Gene | SH3TC1 |
| Organism | Homo sapiens |
| Length | 1336 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- aspartate aminotransferase measurement · score 0.33
- low density lipoprotein cholesterol measurement · score 0.30
- total cholesterol measurement · score 0.27
- drug use measurement · score 0.15
- heel bone mineral density · score 0.14
- PHF-tau measurement · score 0.06
- Romano-Ward syndrome · score 0.05
- neurofibrillary tangles measurement · score 0.05
- Arrhythmogenic right ventricular dysplasia · score 0.04
- Familial short QT syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TE82-F1 | alphafold | PREDICTED | 76.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TE82.
Amino-acid sequence (1336 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH3TC1?
The strongest Open Targets associations for SH3TC1 are aspartate aminotransferase measurement, low density lipoprotein cholesterol measurement, total cholesterol measurement, drug use measurement and heel bone mineral density.
How long is the SH3TC1 protein?
The Homo sapiens SH3TC1 protein (UniProt Q8TE82) is 1336 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TE82 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TE82 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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