tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 (NSUN6)
Homo sapiens — UniProt Q8TEA1
Data last refreshed: (UniProt release unknown)
Key facts
tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 (NSUN6) is a protein from Homo sapiens identified by UniProt accession Q8TEA1, 469 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.
- UniProt accession: Q8TEA1; gene symbol NSUN6.
- Organism: Homo sapiens.
- Length: 469 amino acids.
- Top disease associations (Open Targets): adolescent idiopathic scoliosis, schizophrenia and diastolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 |
|---|---|
| UniProt accession | Q8TEA1 |
| Gene | NSUN6 |
| Organism | Homo sapiens |
| Length | 469 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (75)
Diseases linked to this target (Open Targets).
- adolescent idiopathic scoliosis · score 0.26
- schizophrenia · score 0.17
- diastolic blood pressure · score 0.14
- Beta blocking agent use measurement · score 0.13
- systolic blood pressure · score 0.12
- hypertension · score 0.11
- Agents acting on the renin-angiotensin system use measurement · score 0.11
- self reported educational attainment · score 0.11
- intelligence · score 0.11
- Calcium channel blocker use measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TEA1-F1 | alphafold | PREDICTED | 94.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TEA1.
Amino-acid sequence (469 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NSUN6?
The strongest Open Targets associations for NSUN6 are adolescent idiopathic scoliosis, schizophrenia, diastolic blood pressure, Beta blocking agent use measurement and systolic blood pressure.
How long is the NSUN6 protein?
The Homo sapiens NSUN6 protein (UniProt Q8TEA1) is 469 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TEA1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TEA1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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