TBC domain-containing protein kinase-like protein (TBCK)
Homo sapiens — UniProt Q8TEA7
Data last refreshed: (UniProt release unknown)
Key facts
TBC domain-containing protein kinase-like protein (TBCK) is a protein from Homo sapiens identified by UniProt accession Q8TEA7, 893 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q8TEA7; gene symbol TBCK.
- Organism: Homo sapiens.
- Length: 893 amino acids.
- Top disease associations (Open Targets): hypotonia, infantile, with psychomotor retardation and characteristic facies, genetic disorder and Seizure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TBC domain-containing protein kinase-like protein |
|---|---|
| UniProt accession | Q8TEA7 |
| Gene | TBCK |
| Organism | Homo sapiens |
| Length | 893 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- hypotonia, infantile, with psychomotor retardation and characteristic facies · score 0.69
- genetic disorder · score 0.50
- Seizure · score 0.43
- Abnormality of the nervous system · score 0.43
- Global developmental delay · score 0.41
- Intellectual disability · score 0.34
- Neurodevelopmental disorder · score 0.34
- Hypotonia · score 0.26
- atrial heart septal defect · score 0.26
- balding measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TEA7-F1 | alphafold | PREDICTED | 86.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TEA7.
Amino-acid sequence (893 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TBCK?
The strongest Open Targets associations for TBCK are hypotonia, infantile, with psychomotor retardation and characteristic facies, genetic disorder, Seizure, Abnormality of the nervous system and Global developmental delay.
How long is the TBCK protein?
The Homo sapiens TBCK protein (UniProt Q8TEA7) is 893 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TEA7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TEA7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.