DDB1- and CUL4-associated factor 11 (DCAF11)
Homo sapiens — UniProt Q8TEB1
Data last refreshed: (UniProt release unknown)
Key facts
DDB1- and CUL4-associated factor 11 (DCAF11) is a protein from Homo sapiens identified by UniProt accession Q8TEB1, 546 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q8TEB1; gene symbol DCAF11.
- Organism: Homo sapiens.
- Length: 546 amino acids.
- Top disease associations (Open Targets): body height, Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 and alpha thalassemia-intellectual disability syndrome type 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DDB1- and CUL4-associated factor 11 |
|---|---|
| UniProt accession | Q8TEB1 |
| Gene | DCAF11 |
| Organism | Homo sapiens |
| Length | 546 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- body height · score 0.17
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.06
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.06
- primary familial polycythemia due to EPO receptor mutation · score 0.06
- Pyruvate kinase hyperactivity · score 0.06
- macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.05
- Blackfan-Diamond anemia · score 0.05
- hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.05
- erythrocytosis, familial, 6 · score 0.05
- erythrocytosis, familial, 3 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TEB1-F1 | alphafold | PREDICTED | 82.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TEB1.
Amino-acid sequence (546 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DCAF11?
The strongest Open Targets associations for DCAF11 are body height, Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16, alpha thalassemia-intellectual disability syndrome type 1, primary familial polycythemia due to EPO receptor mutation and Pyruvate kinase hyperactivity.
How long is the DCAF11 protein?
The Homo sapiens DCAF11 protein (UniProt Q8TEB1) is 546 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TEB1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TEB1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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