E3 ubiquitin-protein ligase RNF128 (RNF128)

About E3 ubiquitin-protein ligase RNF128

E3 ubiquitin-protein ligase RNF128 (RNF128) is a protein from Homo sapiens identified by UniProt accession Q8TEB7, 428 residues long. MolForge cross-references it against 0 known binders and 226 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNF128
UniProt accession	Q8TEB7
Gene	RNF128
Organism	Homo sapiens
Length	428 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (226)

Diseases linked to this target (Open Targets).

creatinine measurement · score 0.46
glioblastoma multiforme · score 0.26
breast adenocarcinoma · score 0.25
lung adenocarcinoma · score 0.19
head and neck squamous cell carcinoma · score 0.18
gastric adenocarcinoma · score 0.18
squamous cell lung carcinoma · score 0.18
small cell lung carcinoma · score 0.16
neutropenia · score 0.12
melanoma · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TEB7-F1	alphafold	PREDICTED	75.49	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TEB7.

Amino-acid sequence (428 residues)

MGPPPGAGVS CRGGCGFSRL LAWCFLLALS PQAPGSRGAE AVWTAYLNVS WRVPHTGVNR TVWELSEEGV YGQDSPLEPV AGVLVPPDGP GALNACNPHT NFTVPTVWGS TVQVSWLALI QRGGGCTFAD KIHLAYERGA SGAVIFNFPG TRNEVIPMSH PGAVDIVAIM IGNLKGTKIL QSIQRGIQVT MVIEVGKKHG PWVNHYSIFF VSVSFFIITA ATVGYFIFYS ARRLRNARAQ SRKQRQLKAD AKKAIGRLQL RTLKQGDKEI GPDGDSCAVC IELYKPNDLV RILTCNHIFH KTCVDPWLLE HRTCPMCKCD ILKALGIEVD VEDGSVSLQV PVSNEISNSA SSHEEDNRSE TASSGYASVQ GTDEPPLEEH VQSTNESLQL VNHEANSVAV DVIPHVDNPT FEEDETPNQE TAVREIKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards