E3 ubiquitin-protein ligase SH3RF2 (SH3RF2)
Homo sapiens — UniProt Q8TEC5
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase SH3RF2 (SH3RF2) is a protein from Homo sapiens identified by UniProt accession Q8TEC5, 729 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.
- UniProt accession: Q8TEC5; gene symbol SH3RF2.
- Organism: Homo sapiens.
- Length: 729 amino acids.
- Top disease associations (Open Targets): electrocardiography, neurodegenerative disease and protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase SH3RF2 |
|---|---|
| UniProt accession | Q8TEC5 |
| Gene | SH3RF2 |
| Organism | Homo sapiens |
| Length | 729 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (68)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.40
- neurodegenerative disease · score 0.34
- protein measurement · score 0.29
- Alzheimer disease · score 0.12
- age at onset · score 0.12
- autism · score 0.08
- Autism · score 0.05
- 15q11q13 microduplication syndrome · score 0.05
- Asperger syndrome · score 0.05
- intellectual disability-expressive aphasia-facial dysmorphism syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TEC5-F1 | alphafold | PREDICTED | 57.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TEC5.
Amino-acid sequence (729 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH3RF2?
The strongest Open Targets associations for SH3RF2 are electrocardiography, neurodegenerative disease, protein measurement, Alzheimer disease and age at onset.
How long is the SH3RF2 protein?
The Homo sapiens SH3RF2 protein (UniProt Q8TEC5) is 729 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TEC5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TEC5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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