DENN domain-containing protein 1A (DENND1A)
Homo sapiens — UniProt Q8TEH3
Data last refreshed: (UniProt release unknown)
Key facts
DENN domain-containing protein 1A (DENND1A) is a protein from Homo sapiens identified by UniProt accession Q8TEH3, 1009 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.
- UniProt accession: Q8TEH3; gene symbol DENND1A.
- Organism: Homo sapiens.
- Length: 1009 amino acids.
- Top disease associations (Open Targets): polycystic ovary syndrome, unipolar depression and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DENN domain-containing protein 1A |
|---|---|
| UniProt accession | Q8TEH3 |
| Gene | DENND1A |
| Organism | Homo sapiens |
| Length | 1009 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (85)
Diseases linked to this target (Open Targets).
- polycystic ovary syndrome · score 0.38
- unipolar depression · score 0.34
- body mass index · score 0.34
- heel bone mineral density · score 0.33
- self reported educational attainment · score 0.30
- neutrophil count · score 0.29
- leukocyte count · score 0.29
- macula measurement · score 0.29
- hair colour measurement · score 0.29
- age at menopause · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TEH3-F1 | alphafold | PREDICTED | 60.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TEH3.
Amino-acid sequence (1009 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DENND1A?
The strongest Open Targets associations for DENND1A are polycystic ovary syndrome, unipolar depression, body mass index, heel bone mineral density and self reported educational attainment.
How long is the DENND1A protein?
The Homo sapiens DENND1A protein (UniProt Q8TEH3) is 1009 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TEH3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TEH3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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