E3 ubiquitin-protein ligase SH3RF3 (SH3RF3)
Homo sapiens — UniProt Q8TEJ3
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase SH3RF3 (SH3RF3) is a protein from Homo sapiens identified by UniProt accession Q8TEJ3, 882 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.
- UniProt accession: Q8TEJ3; gene symbol SH3RF3.
- Organism: Homo sapiens.
- Length: 882 amino acids.
- Top disease associations (Open Targets): cortical surface area measurement, cortical thickness and brain measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase SH3RF3 |
|---|---|
| UniProt accession | Q8TEJ3 |
| Gene | SH3RF3 |
| Organism | Homo sapiens |
| Length | 882 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (42)
Diseases linked to this target (Open Targets).
- cortical surface area measurement · score 0.41
- cortical thickness · score 0.38
- brain measurement · score 0.38
- neuroimaging measurement · score 0.38
- heel bone mineral density · score 0.37
- neurodegenerative disease · score 0.31
- handedness · score 0.30
- body fat percentage · score 0.30
- body height · score 0.30
- BMI-adjusted waist circumference · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TEJ3-F1 | alphafold | PREDICTED | 57.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TEJ3.
Amino-acid sequence (882 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH3RF3?
The strongest Open Targets associations for SH3RF3 are cortical surface area measurement, cortical thickness, brain measurement, neuroimaging measurement and heel bone mineral density.
How long is the SH3RF3 protein?
The Homo sapiens SH3RF3 protein (UniProt Q8TEJ3) is 882 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TEJ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TEJ3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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