Histone-lysine N-methyltransferase, H3 lysine-79 specific (DOT1L)

Homo sapiens — UniProt Q8TEK3

Gene: DOT1LHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Histone-lysine N-methyltransferase, H3 lysine-79 specific (DOT1L) is a protein from Homo sapiens identified by UniProt accession Q8TEK3, 1537 residues long. MolForge cross-references it against 1 known binders and 218 disease associations.

UniProt accession: Q8TEK3; gene symbol DOT1L.
Organism: Homo sapiens.
Length: 1537 amino acids.
Top disease associations (Open Targets): lean body mass, erythrocyte count and hemoglobin measurement.
3D structure: AlphaFold model available.

Target properties

Protein name	Histone-lysine N-methyltransferase, H3 lysine-79 specific
UniProt accession	Q8TEK3
Gene	DOT1L
Organism	Homo sapiens
Length	1537 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (218)

Diseases linked to this target (Open Targets).

lean body mass · score 0.39
erythrocyte count · score 0.39
hemoglobin measurement · score 0.38
waist-hip ratio · score 0.36
pulse pressure measurement · score 0.35
hematocrit · score 0.35
BMI-adjusted waist-hip ratio · score 0.35
genetic disorder · score 0.34
heel bone mineral density · score 0.34
appendicular lean mass · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TEK3-F1	alphafold	PREDICTED	52.50	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TEK3.

Amino-acid sequence (1537 residues)

MGEKLELRLK SPVGAEPAVY PWPLPVYDKH HDAAHEIIET IRWVCEEIPD LKLAMENYVL IDYDTKSFES MQRLCDKYNR AIDSIHQLWK GTTQPMKLNT RPSTGLLRHI LQQVYNHSVT DPEKLNNYEP FSPEVYGETS FDLVAQMIDE IKMTDDDLFV DLGSGVGQVV LQVAAATNCK HHYGVEKADI PAKYAETMDR EFRKWMKWYG KKHAEYTLER GDFLSEEWRE RIANTSVIFV NNFAFGPEVD HQLKERFANM KEGGRIVSSK PFAPLNFRIN SRNLSDIGTI MRVVELSPLK GSVSWTGKPV SYYLHTIDRT ILENYFSSLK NPKLREEQEA ARRRQQRESK SNAATPTKGP EGKVAGPADA PMDSGAEEEK AGAATVKKPS PSKARKKKLN KKGRKMAGRK RGRPKKMNTA NPERKPKKNQ TALDALHAQT VSQTAASSPQ DAYRSPHSPF YQLPPSVQRH SPNPLLVAPT PPALQKLLES FKIQYLQFLA YTKTPQYKAS LQELLGQEKE KNAQLLGAAQ QLLSHCQAQK EEIRRLFQQK LDELGVKALT YNDLIQAQKE ISAHNQQLRE QSEQLEQDNR ALRGQSLQLL KARCEELQLD WATLSLEKLL KEKQALKSQI SEKQRHCLEL QISIVELEKS QRQQELLQLK SCVPPDDALS LHLRGKGALG RELEPDASRL HLELDCTKFS LPHLSSMSPE LSMNGQAAGY ELCGVLSRPS SKQNTPQYLA SPLDQEVVPC TPSHVGRPRL EKLSGLAAPD YTRLSPAKIV LRRHLSQDHT VPGRPAASEL HSRAEHTKEN GLPYQSPSVP GSMKLSPQDP RPLSPGALQL AGEKSSEKGL RERAYGSSGE LITSLPISIP LSTVQPNKLP VSIPLASVVL PSRAERARST PSPVLQPRDP SSTLEKQIGA NAHGAGSRSL ALAPAGFSYA GSVAISGALA GSPASLTPGA EPATLDESSS SGSLFATVGS RSSTPQHPLL LAQPRNSLPA SPAHQLSSSP RLGGAAQGPL PEASKGDLPS DSGFSDPESE AKRRIVFTIT TGAGSAKQSP SSKHSPLTAS ARGDCVPSHG QDSRRRGRRK RASAGTPSLS AGVSPKRRAL PSVAGLFTQP SGSPLNLNSM VSNINQPLEI TAISSPETSL KSSPVPYQDH DQPPVLKKER PLSQTNGAHY SPLTSDEEPG SEDEPSSARI ERKIATISLE SKSPPKTLEN GGGLAGRKPA PAGEPVNSSK WKSTFSPISD IGLAKSADSP LQASSALSQN SLFTFRPALE EPSADAKLAA HPRKGFPGSL SGADGLSPGT NPANGCTFGG GLAADLSLHS FSDGASLPHK GPEAAGLSSP LSFPSQRGKE GSDANPFLSK RQLDGLAGLK GEGSRGKEAG EGGLPLCGPT DKTPLLSGKA AKARDREVDL KNGHNLFISA AAVPPGSLLS GPGLAPAASS AGGAASSAQT HRSFLGPFPP GPQFALGPMS LQANLGSVAG SSVLQSLFSS VPAAAGLVHV SSAATRLTNS HAMGSFSGVA GGTVGGN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with DOT1L?

The strongest Open Targets associations for DOT1L are lean body mass, erythrocyte count, hemoglobin measurement, waist-hip ratio and pulse pressure measurement.

How long is the DOT1L protein?

The Homo sapiens DOT1L protein (UniProt Q8TEK3) is 1537 amino acids long.

Browse: Targets: D · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q8TEK3 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q8TEK3 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

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