Gem-associated protein 5 (GEMIN5)

Homo sapiens — UniProt Q8TEQ6

Gene: GEMIN5Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Gem-associated protein 5 (GEMIN5) is a protein from Homo sapiens identified by UniProt accession Q8TEQ6, 1508 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

UniProt accession: Q8TEQ6; gene symbol GEMIN5.
Organism: Homo sapiens.
Length: 1508 amino acids.
Top disease associations (Open Targets): genetic disorder, neurodegenerative disease and erythrocyte count.
3D structure: AlphaFold model available.

Target properties

Protein name	Gem-associated protein 5
UniProt accession	Q8TEQ6
Gene	GEMIN5
Organism	Homo sapiens
Length	1508 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (70)

Diseases linked to this target (Open Targets).

genetic disorder · score 0.50
neurodegenerative disease · score 0.46
erythrocyte count · score 0.40
autosomal recessive non-syndromic intellectual disability · score 0.37
mean corpuscular hemoglobin · score 0.36
mean corpuscular volume · score 0.30
adolescent idiopathic scoliosis · score 0.27
reticulocyte measurement · score 0.27
mean corpuscular hemoglobin concentration · score 0.27
age at menopause · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8TEQ6-F1	alphafold	PREDICTED	78.91	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TEQ6.

Amino-acid sequence (1508 residues)

MGQEPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPGAGESPG TPPFRVIGEL VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKT VVTEHALHQH TISTLHWSPR VKDLIVSGDE KGVVFCYWFN RNDSQHLFIE PRTIFCLTCS PHHEDLVAIG YKDGIVVIID ISKKGEVIHR LRGHDDEIHS IAWCPLPGED CLSINQEETS EEAEITNGNA VAQAPVTKGC YLATGSKDQT IRIWSCSRGR GVMILKLPFL KRRGGGIDPT VKERLWLTLH WPSNQPTQLV SSCFGGELLQ WDLTQSWRRK YTLFSASSEG QNHSRIVFNL CPLQTEDDKQ LLLSTSMDRD VKCWDIATLE CSWTLPSLGG FAYSLAFSSV DIGSLAIGVG DGMIRVWNTL SIKNNYDVKN FWQGVKSKVT ALCWHPTKEG CLAFGTDDGK VGLYDTYSNK PPQISSTYHK KTVYTLAWGP PVPPMSLGGE GDRPSLALYS CGGEGIVLQH NPWKLSGEAF DINKLIRDTN SIKYKLPVHT EISWKADGKI MALGNEDGSI EIFQIPNLKL ICTIQQHHKL VNTISWHHEH GSQPELSYLM ASGSNNAVIY VHNLKTVIES SPESPVTITE PYRTLSGHTA KITSVAWSPH HDGRLVSASY DGTAQVWDAL REEPLCNFRG HRGRLLCVAW SPLDPDCIYS GADDFCVHKW LTSMQDHSRP PQGKKSIELE KKRLSQPKAK PKKKKKPTLR TPVKLESIDG NEEESMKENS GPVENGVSDQ EGEEQAREPE LPCGLAPAVS REPVICTPVS SGFEKSKVTI NNKVILLKKE PPKEKPETLI KKRKARSLLP LSTSLDHRSK EELHQDCLVL ATAKHSRELN EDVSADVEER FHLGLFTDRA TLYRMIDIEG KGHLENGHPE LFHQLMLWKG DLKGVLQTAA ERGELTDNLV AMAPAAGYHV WLWAVEAFAK QLCFQDQYVK AASHLLSIHK VYEAVELLKS NHFYREAIAI AKARLRPEDP VLKDLYLSWG TVLERDGHYA VAAKCYLGAT CAYDAAKVLA KKGDAASLRT AAELAAIVGE DELSASLALR CAQELLLANN WVGAQEALQL HESLQGQRLV FCLLELLSRH LEEKQLSEGK SSSSYHTWNT GTEGPFVERV TAVWKSIFSL DTPEQYQEAF QKLQNIKYPS ATNNTPAKQL LLHICHDLTL AVLSQQMASW DEAVQALLRA VVRSYDSGSF TIMQEVYSAF LPDGCDHLRD KLGDHQSPAT PAFKSLEAFF LYGRLYEFWW SLSRPCPNSS VWVRAGHRTL SVEPSQQLDT ASTEETDPET SQPEPNRPSE LDLRLTEEGE RMLSTFKELF SEKHASLQNS QRTVAEVQET LAEMIRQHQK SQLCKSTANG PDKNEPEVEA EQPLCSSQSQ CKEEKNEPLS LPELTKRLTE ANQRMAKFPE SIKAWPFPDV LECCLVLLLI RSHFPGCLAQ EMQQQAQELL QKYGNTKTYR RHCQTFCM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with GEMIN5?

The strongest Open Targets associations for GEMIN5 are genetic disorder, neurodegenerative disease, erythrocyte count, autosomal recessive non-syndromic intellectual disability and mean corpuscular hemoglobin.

How long is the GEMIN5 protein?

The Homo sapiens GEMIN5 protein (UniProt Q8TEQ6) is 1508 amino acids long.

Browse: Targets: G · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q8TEQ6 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q8TEQ6 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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