GPI ethanolamine phosphate transferase 3, catalytic subunit (PIGO)
Homo sapiens — UniProt Q8TEQ8
Data last refreshed: (UniProt release unknown)
Key facts
GPI ethanolamine phosphate transferase 3, catalytic subunit (PIGO) is a protein from Homo sapiens identified by UniProt accession Q8TEQ8, 1089 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q8TEQ8; gene symbol PIGO.
- Organism: Homo sapiens.
- Length: 1089 amino acids.
- Top disease associations (Open Targets): hyperphosphatasia-intellectual disability syndrome, genetic disorder and complex neurodevelopmental disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GPI ethanolamine phosphate transferase 3, catalytic subunit |
|---|---|
| UniProt accession | Q8TEQ8 |
| Gene | PIGO |
| Organism | Homo sapiens |
| Length | 1089 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- hyperphosphatasia-intellectual disability syndrome · score 0.71
- genetic disorder · score 0.41
- complex neurodevelopmental disorder · score 0.37
- Aganglionic megacolon · score 0.12
- Hirschsprung disease · score 0.12
- Intellectual disability · score 0.11
- Familial short QT syndrome · score 0.05
- mean corpuscular hemoglobin concentration · score 0.05
- familial atrial fibrillation · score 0.05
- catecholaminergic polymorphic ventricular tachycardia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TEQ8-F1 | alphafold | PREDICTED | 82.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TEQ8.
Amino-acid sequence (1089 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIGO?
The strongest Open Targets associations for PIGO are hyperphosphatasia-intellectual disability syndrome, genetic disorder, complex neurodevelopmental disorder, Aganglionic megacolon and Hirschsprung disease.
How long is the PIGO protein?
The Homo sapiens PIGO protein (UniProt Q8TEQ8) is 1089 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TEQ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TEQ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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