Guanine nucleotide exchange protein SMCR8 (SMCR8)
Homo sapiens — UniProt Q8TEV9
Data last refreshed: (UniProt release unknown)
Key facts
Guanine nucleotide exchange protein SMCR8 (SMCR8) is a protein from Homo sapiens identified by UniProt accession Q8TEV9, 937 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.
- UniProt accession: Q8TEV9; gene symbol SMCR8.
- Organism: Homo sapiens.
- Length: 937 amino acids.
- Top disease associations (Open Targets): Red cell distribution width, diastolic blood pressure and BMI-adjusted waist-hip ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Guanine nucleotide exchange protein SMCR8 |
|---|---|
| UniProt accession | Q8TEV9 |
| Gene | SMCR8 |
| Organism | Homo sapiens |
| Length | 937 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (118)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.21
- diastolic blood pressure · score 0.18
- BMI-adjusted waist-hip ratio · score 0.17
- serum alanine aminotransferase measurement · score 0.16
- systolic blood pressure · score 0.15
- BMI-adjusted waist circumference · score 0.14
- protein measurement · score 0.14
- mitochondrial DNA measurement · score 0.12
- Neurodevelopmental disorder · score 0.12
- heart rate · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TEV9-F1 | alphafold | PREDICTED | 62.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TEV9.
Amino-acid sequence (937 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMCR8?
The strongest Open Targets associations for SMCR8 are Red cell distribution width, diastolic blood pressure, BMI-adjusted waist-hip ratio, serum alanine aminotransferase measurement and systolic blood pressure.
How long is the SMCR8 protein?
The Homo sapiens SMCR8 protein (UniProt Q8TEV9) is 937 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TEV9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TEV9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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