Membrane progestin receptor beta (PAQR8)
Homo sapiens — UniProt Q8TEZ7
Data last refreshed: (UniProt release unknown)
Key facts
Membrane progestin receptor beta (PAQR8) is a protein from Homo sapiens identified by UniProt accession Q8TEZ7, 354 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q8TEZ7; gene symbol PAQR8.
- Organism: Homo sapiens.
- Length: 354 amino acids.
- Top disease associations (Open Targets): mean platelet volume, platelet count and platelet component distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Membrane progestin receptor beta |
|---|---|
| UniProt accession | Q8TEZ7 |
| Gene | PAQR8 |
| Organism | Homo sapiens |
| Length | 354 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.44
- platelet count · score 0.43
- platelet component distribution width · score 0.27
- neutrophil count · score 0.18
- peak expiratory flow · score 0.15
- appendicular lean mass · score 0.13
- eosinophil count · score 0.12
- sex hormone-binding globulin measurement · score 0.11
- leukocyte count · score 0.10
- neoplasm · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8TEZ7-F1 | alphafold | PREDICTED | 93.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8TEZ7.
Amino-acid sequence (354 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PAQR8?
The strongest Open Targets associations for PAQR8 are mean platelet volume, platelet count, platelet component distribution width, neutrophil count and peak expiratory flow.
How long is the PAQR8 protein?
The Homo sapiens PAQR8 protein (UniProt Q8TEZ7) is 354 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8TEZ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8TEZ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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