1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5)
Homo sapiens — UniProt Q8WTS1
Data last refreshed: (UniProt release unknown)
Key facts
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) is a protein from Homo sapiens identified by UniProt accession Q8WTS1, 349 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.
- UniProt accession: Q8WTS1; gene symbol ABHD5.
- Organism: Homo sapiens.
- Length: 349 amino acids.
- Top disease associations (Open Targets): Dorfman-Chanarin disease, BMI-adjusted waist-hip ratio and BMI-adjusted waist circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 |
|---|---|
| UniProt accession | Q8WTS1 |
| Gene | ABHD5 |
| Organism | Homo sapiens |
| Length | 349 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (120)
Diseases linked to this target (Open Targets).
- Dorfman-Chanarin disease · score 0.82
- BMI-adjusted waist-hip ratio · score 0.28
- BMI-adjusted waist circumference · score 0.21
- genetic disorder · score 0.19
- psoriasis · score 0.18
- PHF-tau measurement · score 0.18
- attention deficit hyperactivity disorder · score 0.17
- antisocial behaviour measurement · score 0.16
- substance abuse · score 0.16
- self reported educational attainment · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WTS1-F1 | alphafold | PREDICTED | 87.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WTS1.
Amino-acid sequence (349 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ABHD5?
The strongest Open Targets associations for ABHD5 are Dorfman-Chanarin disease, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, genetic disorder and psoriasis.
How long is the ABHD5 protein?
The Homo sapiens ABHD5 protein (UniProt Q8WTS1) is 349 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WTS1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WTS1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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