Scavenger receptor class B member 1 (SCARB1)
Homo sapiens — UniProt Q8WTV0
Data last refreshed: (UniProt release unknown)
Key facts
Scavenger receptor class B member 1 (SCARB1) is a protein from Homo sapiens identified by UniProt accession Q8WTV0, 552 residues long. MolForge cross-references it against 0 known binders and 577 disease associations.
- UniProt accession: Q8WTV0; gene symbol SCARB1.
- Organism: Homo sapiens.
- Length: 552 amino acids.
- Top disease associations (Open Targets): high density lipoprotein cholesterol measurement, lipoprotein measurement and total cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Scavenger receptor class B member 1 |
|---|---|
| UniProt accession | Q8WTV0 |
| Gene | SCARB1 |
| Organism | Homo sapiens |
| Length | 552 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (577)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.71
- lipoprotein measurement · score 0.64
- total cholesterol measurement · score 0.63
- apolipoprotein A 1 measurement · score 0.60
- cholesteryl ester measurement · score 0.55
- phospholipids:total lipids ratio · score 0.54
- concentration of large HDL particles measurement · score 0.54
- Alzheimer disease · score 0.53
- phospholipids in very large HDL measurement · score 0.48
- total lipids in very large HDL measurement · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WTV0-F1 | alphafold | PREDICTED | 83.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WTV0.
Amino-acid sequence (552 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SCARB1?
The strongest Open Targets associations for SCARB1 are high density lipoprotein cholesterol measurement, lipoprotein measurement, total cholesterol measurement, apolipoprotein A 1 measurement and cholesteryl ester measurement.
How long is the SCARB1 protein?
The Homo sapiens SCARB1 protein (UniProt Q8WTV0) is 552 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WTV0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WTV0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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