THAP domain-containing protein 3 (THAP3)
Homo sapiens — UniProt Q8WTV1
Data last refreshed: (UniProt release unknown)
Key facts
THAP domain-containing protein 3 (THAP3) is a protein from Homo sapiens identified by UniProt accession Q8WTV1, 239 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q8WTV1; gene symbol THAP3.
- Organism: Homo sapiens.
- Length: 239 amino acids.
- Top disease associations (Open Targets): FEV/FVC ratio, body mass index and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | THAP domain-containing protein 3 |
|---|---|
| UniProt accession | Q8WTV1 |
| Gene | THAP3 |
| Organism | Homo sapiens |
| Length | 239 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.30
- body mass index · score 0.27
- heel bone mineral density · score 0.26
- systolic blood pressure · score 0.26
- body fat percentage · score 0.25
- sex hormone-binding globulin measurement · score 0.21
- pulse pressure measurement · score 0.20
- peak expiratory flow · score 0.19
- bone quantitative ultrasound measurement · score 0.18
- aspartate aminotransferase measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WTV1-F1 | alphafold | PREDICTED | 70.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WTV1.
Amino-acid sequence (239 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with THAP3?
The strongest Open Targets associations for THAP3 are FEV/FVC ratio, body mass index, heel bone mineral density, systolic blood pressure and body fat percentage.
How long is the THAP3 protein?
The Homo sapiens THAP3 protein (UniProt Q8WTV1) is 239 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WTV1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WTV1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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