Conserved oligomeric Golgi complex subunit 1 (COG1)
Homo sapiens — UniProt Q8WTW3
Data last refreshed: (UniProt release unknown)
Key facts
Conserved oligomeric Golgi complex subunit 1 (COG1) is a protein from Homo sapiens identified by UniProt accession Q8WTW3, 980 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q8WTW3; gene symbol COG1.
- Organism: Homo sapiens.
- Length: 980 amino acids.
- Top disease associations (Open Targets): COG1-congenital disorder of glycosylation, neurodegenerative disease and erythrocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Conserved oligomeric Golgi complex subunit 1 |
|---|---|
| UniProt accession | Q8WTW3 |
| Gene | COG1 |
| Organism | Homo sapiens |
| Length | 980 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- COG1-congenital disorder of glycosylation · score 0.79
- neurodegenerative disease · score 0.37
- erythrocyte count · score 0.26
- Red cell distribution width · score 0.26
- mean corpuscular hemoglobin · score 0.24
- mean corpuscular volume · score 0.23
- mean reticulocyte volume · score 0.23
- genetic disorder · score 0.19
- red blood cell density measurement · score 0.19
- congenital disorder of glycosylation · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WTW3-F1 | alphafold | PREDICTED | 77.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WTW3.
Amino-acid sequence (980 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COG1?
The strongest Open Targets associations for COG1 are COG1-congenital disorder of glycosylation, neurodegenerative disease, erythrocyte count, Red cell distribution width and mean corpuscular hemoglobin.
How long is the COG1 protein?
The Homo sapiens COG1 protein (UniProt Q8WTW3) is 980 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WTW3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WTW3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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