GATOR1 complex protein NPRL2 (NPRL2)
Homo sapiens — UniProt Q8WTW4
Data last refreshed: (UniProt release unknown)
Key facts
GATOR1 complex protein NPRL2 (NPRL2) is a protein from Homo sapiens identified by UniProt accession Q8WTW4, 380 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q8WTW4; gene symbol NPRL2.
- Organism: Homo sapiens.
- Length: 380 amino acids.
- Top disease associations (Open Targets): familial focal epilepsy with variable foci, neurodegenerative disease and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GATOR1 complex protein NPRL2 |
|---|---|
| UniProt accession | Q8WTW4 |
| Gene | NPRL2 |
| Organism | Homo sapiens |
| Length | 380 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- familial focal epilepsy with variable foci · score 0.70
- neurodegenerative disease · score 0.42
- genetic disorder · score 0.41
- partial epilepsy · score 0.38
- Seizure · score 0.33
- brain-lung-thyroid syndrome · score 0.27
- pancreatic neuroendocrine tumor · score 0.25
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.08
- gastric adenocarcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WTW4-F1 | alphafold | PREDICTED | 69.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WTW4.
Amino-acid sequence (380 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NPRL2?
The strongest Open Targets associations for NPRL2 are familial focal epilepsy with variable foci, neurodegenerative disease, genetic disorder, partial epilepsy and Seizure.
How long is the NPRL2 protein?
The Homo sapiens NPRL2 protein (UniProt Q8WTW4) is 380 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WTW4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WTW4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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