tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1 (PYROXD1)
Homo sapiens — UniProt Q8WU10
Data last refreshed: (UniProt release unknown)
Key facts
tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1 (PYROXD1) is a protein from Homo sapiens identified by UniProt accession Q8WU10, 500 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.
- UniProt accession: Q8WU10; gene symbol PYROXD1.
- Organism: Homo sapiens.
- Length: 500 amino acids.
- Top disease associations (Open Targets): myofibrillar myopathy 8, blood protein measurement and hereditary neoplastic syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1 |
|---|---|
| UniProt accession | Q8WU10 |
| Gene | PYROXD1 |
| Organism | Homo sapiens |
| Length | 500 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (89)
Diseases linked to this target (Open Targets).
- myofibrillar myopathy 8 · score 0.72
- blood protein measurement · score 0.30
- hereditary neoplastic syndrome · score 0.20
- Inherited cancer-predisposing syndrome · score 0.20
- genetic disorder · score 0.19
- Muscular dystrophy · score 0.19
- muscular dystrophy · score 0.19
- neurodegenerative disease · score 0.17
- hereditary breast ovarian cancer syndrome · score 0.12
- Hereditary breast and ovarian cancer syndrome · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WU10-F1 | alphafold | PREDICTED | 88.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WU10.
Amino-acid sequence (500 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PYROXD1?
The strongest Open Targets associations for PYROXD1 are myofibrillar myopathy 8, blood protein measurement, hereditary neoplastic syndrome, Inherited cancer-predisposing syndrome and genetic disorder.
How long is the PYROXD1 protein?
The Homo sapiens PYROXD1 protein (UniProt Q8WU10) is 500 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WU10 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WU10 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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