E3 ubiquitin-protein ligase RNF139 (RNF139)
Homo sapiens — UniProt Q8WU17
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF139 (RNF139) is a protein from Homo sapiens identified by UniProt accession Q8WU17, 664 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q8WU17; gene symbol RNF139.
- Organism: Homo sapiens.
- Length: 664 amino acids.
- Top disease associations (Open Targets): neoplasm, hepatocellular carcinoma and Congenital bile acid synthesis defect type 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF139 |
|---|---|
| UniProt accession | Q8WU17 |
| Gene | RNF139 |
| Organism | Homo sapiens |
| Length | 664 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.06
- hepatocellular carcinoma · score 0.06
- Congenital bile acid synthesis defect type 1 · score 0.04
- gallbladder disease · score 0.04
- progressive familial intrahepatic cholestasis type 2 · score 0.04
- complement component C1s deficiency · score 0.04
- mean platelet volume · score 0.04
- cholestasis, progressive familial intrahepatic, 7, with or without hearing loss · score 0.04
- transient infantile hypertriglyceridemia and hepatosteatosis · score 0.04
- sclerosing cholangitis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WU17-F1 | alphafold | PREDICTED | 79.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WU17.
Amino-acid sequence (664 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF139?
The strongest Open Targets associations for RNF139 are neoplasm, hepatocellular carcinoma, Congenital bile acid synthesis defect type 1, gallbladder disease and progressive familial intrahepatic cholestasis type 2.
How long is the RNF139 protein?
The Homo sapiens RNF139 protein (UniProt Q8WU17) is 664 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WU17 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WU17 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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