Fibroblast growth factor receptor substrate 2 (FRS2)
Homo sapiens — UniProt Q8WU20
Data last refreshed: (UniProt release unknown)
Key facts
Fibroblast growth factor receptor substrate 2 (FRS2) is a protein from Homo sapiens identified by UniProt accession Q8WU20, 508 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.
- UniProt accession: Q8WU20; gene symbol FRS2.
- Organism: Homo sapiens.
- Length: 508 amino acids.
- Top disease associations (Open Targets): cancer, bone development disease and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Fibroblast growth factor receptor substrate 2 |
|---|---|
| UniProt accession | Q8WU20 |
| Gene | FRS2 |
| Organism | Homo sapiens |
| Length | 508 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (110)
Diseases linked to this target (Open Targets).
- cancer · score 0.60
- bone development disease · score 0.59
- neurodegenerative disease · score 0.50
- body height · score 0.40
- forced expiratory volume · score 0.36
- lean body mass · score 0.35
- BMI-adjusted hip circumference · score 0.35
- heel bone mineral density · score 0.35
- appendicular lean mass · score 0.33
- BMI-adjusted waist circumference · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WU20-F1 | alphafold | PREDICTED | 57.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WU20.
Amino-acid sequence (508 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FRS2?
The strongest Open Targets associations for FRS2 are cancer, bone development disease, neurodegenerative disease, body height and forced expiratory volume.
How long is the FRS2 protein?
The Homo sapiens FRS2 protein (UniProt Q8WU20) is 508 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WU20 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WU20 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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