Marginal zone B- and B1-cell-specific protein (MZB1)
Homo sapiens — UniProt Q8WU39
Data last refreshed: (UniProt release unknown)
Key facts
Marginal zone B- and B1-cell-specific protein (MZB1) is a protein from Homo sapiens identified by UniProt accession Q8WU39, 189 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.
- UniProt accession: Q8WU39; gene symbol MZB1.
- Organism: Homo sapiens.
- Length: 189 amino acids.
- Top disease associations (Open Targets): creatinine measurement, breast cancer and Systemic lupus erythematosus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Marginal zone B- and B1-cell-specific protein |
|---|---|
| UniProt accession | Q8WU39 |
| Gene | MZB1 |
| Organism | Homo sapiens |
| Length | 189 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (136)
Diseases linked to this target (Open Targets).
- creatinine measurement · score 0.08
- breast cancer · score 0.08
- Systemic lupus erythematosus · score 0.07
- Rheumatoid arthritis · score 0.06
- Barrett's esophagus · score 0.05
- neoplasm · score 0.05
- severe congenital hypochromic anemia with ringed sideroblasts · score 0.05
- combined immunodeficiency with skin granulomas · score 0.05
- microcytic anemia with liver iron overload · score 0.05
- interstitial lung disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WU39-F1 | alphafold | PREDICTED | 84.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WU39.
Amino-acid sequence (189 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MZB1?
The strongest Open Targets associations for MZB1 are creatinine measurement, breast cancer, Systemic lupus erythematosus, Rheumatoid arthritis and Barrett's esophagus.
How long is the MZB1 protein?
The Homo sapiens MZB1 protein (UniProt Q8WU39) is 189 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WU39 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WU39 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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