Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSPEAR)
Homo sapiens — UniProt Q8WU66
Data last refreshed: (UniProt release unknown)
Key facts
Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSPEAR) is a protein from Homo sapiens identified by UniProt accession Q8WU66, 669 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q8WU66; gene symbol TSPEAR.
- Organism: Homo sapiens.
- Length: 669 amino acids.
- Top disease associations (Open Targets): autosomal recessive hypohidrotic ectodermal dysplasia, hearing loss, autosomal recessive and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Thrombospondin-type laminin G domain and EAR repeat-containing protein |
|---|---|
| UniProt accession | Q8WU66 |
| Gene | TSPEAR |
| Organism | Homo sapiens |
| Length | 669 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- autosomal recessive hypohidrotic ectodermal dysplasia · score 0.66
- hearing loss, autosomal recessive · score 0.49
- genetic disorder · score 0.47
- deafness · score 0.40
- neurofibrillary tangles measurement · score 0.13
- hair shape measurement · score 0.12
- Hearing impairment · score 0.12
- breast ductal adenocarcinoma · score 0.11
- myoepithelial tumor · score 0.11
- hair colour measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WU66-F1 | alphafold | PREDICTED | 86.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WU66.
Amino-acid sequence (669 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TSPEAR?
The strongest Open Targets associations for TSPEAR are autosomal recessive hypohidrotic ectodermal dysplasia, hearing loss, autosomal recessive, genetic disorder, deafness and neurofibrillary tangles measurement.
How long is the TSPEAR protein?
The Homo sapiens TSPEAR protein (UniProt Q8WU66) is 669 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WU66 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WU66 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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