Splicing factor U2AF 26 kDa subunit (U2AF1L4)

About Splicing factor U2AF 26 kDa subunit

Splicing factor U2AF 26 kDa subunit (U2AF1L4) is a protein from Homo sapiens identified by UniProt accession Q8WU68, 220 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Splicing factor U2AF 26 kDa subunit
UniProt accession	Q8WU68
Gene	U2AF1L4
Organism	Homo sapiens
Length	220 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.22
blood protein measurement · score 0.18
body height · score 0.14
white matter microstructure measurement · score 0.07
age at menarche · score 0.05
eosinophil percentage of leukocytes · score 0.04
self reported educational attainment · score 0.04
mathematical ability · score 0.04
eosinophil count · score 0.04
brain measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8WU68-F1	alphafold	PREDICTED	83.73	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WU68.

Amino-acid sequence (220 residues)

MAEYLASIFG TEKDKVNCSF YFKIGVCRHG DRCSRLHNKP TFSQTIVLLN LYRNPQNTAQ TADGSHCHVS DVEVQEHYDS FFEEVFTELQ EKYGEIEEMN VCDNLGDHLV GNVYVKFRRE EDGERAVAEL SNRWFNGQAV HGELSPVTDF RESCCRQYEM GECTRGGFCN FMHLRPISQN LQRQLYGRGP RRRSPPRFHT GHHPRERNHR CSPDHWHGRF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards