General transcription factor 3C polypeptide 2 (GTF3C2)
Homo sapiens — UniProt Q8WUA4
Data last refreshed: (UniProt release unknown)
Key facts
General transcription factor 3C polypeptide 2 (GTF3C2) is a protein from Homo sapiens identified by UniProt accession Q8WUA4, 911 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q8WUA4; gene symbol GTF3C2.
- Organism: Homo sapiens.
- Length: 911 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, triglyceride measurement and coagulation factor measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | General transcription factor 3C polypeptide 2 |
|---|---|
| UniProt accession | Q8WUA4 |
| Gene | GTF3C2 |
| Organism | Homo sapiens |
| Length | 911 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- triglyceride measurement · score 0.04
- coagulation factor measurement · score 0.04
- type 2 diabetes mellitus · score 0.04
- urinary albumin to creatinine ratio · score 0.04
- blood protein measurement · score 0.04
- low density lipoprotein cholesterol measurement · score 0.04
- age at menopause · score 0.04
- alcohol consumption measurement · score 0.04
- mean corpuscular hemoglobin concentration · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WUA4-F1 | alphafold | PREDICTED | 72.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WUA4.
Amino-acid sequence (911 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GTF3C2?
The strongest Open Targets associations for GTF3C2 are neurodegenerative disease, triglyceride measurement, coagulation factor measurement, type 2 diabetes mellitus and urinary albumin to creatinine ratio.
How long is the GTF3C2 protein?
The Homo sapiens GTF3C2 protein (UniProt Q8WUA4) is 911 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WUA4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WUA4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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