TBC1 domain family member 22A (TBC1D22A)
Homo sapiens — UniProt Q8WUA7
Data last refreshed: (UniProt release unknown)
Key facts
TBC1 domain family member 22A (TBC1D22A) is a protein from Homo sapiens identified by UniProt accession Q8WUA7, 517 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q8WUA7; gene symbol TBC1D22A.
- Organism: Homo sapiens.
- Length: 517 amino acids.
- Top disease associations (Open Targets): waist-hip ratio, cortical thickness and BMI-adjusted waist-hip ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TBC1 domain family member 22A |
|---|---|
| UniProt accession | Q8WUA7 |
| Gene | TBC1D22A |
| Organism | Homo sapiens |
| Length | 517 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- waist-hip ratio · score 0.31
- cortical thickness · score 0.30
- BMI-adjusted waist-hip ratio · score 0.28
- cortical surface area measurement · score 0.24
- functional brain measurement · score 0.21
- language measurement · score 0.21
- PHF-tau measurement · score 0.20
- brain measurement · score 0.20
- feeling "fed-up" measurement · score 0.19
- platelet count · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WUA7-F1 | alphafold | PREDICTED | 76.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WUA7.
Amino-acid sequence (517 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TBC1D22A?
The strongest Open Targets associations for TBC1D22A are waist-hip ratio, cortical thickness, BMI-adjusted waist-hip ratio, cortical surface area measurement and functional brain measurement.
How long is the TBC1D22A protein?
The Homo sapiens TBC1D22A protein (UniProt Q8WUA7) is 517 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WUA7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WUA7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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