Transforming growth factor-beta receptor-associated protein 1 (TGFBRAP1)
Homo sapiens — UniProt Q8WUH2
Data last refreshed: (UniProt release unknown)
Key facts
Transforming growth factor-beta receptor-associated protein 1 (TGFBRAP1) is a protein from Homo sapiens identified by UniProt accession Q8WUH2, 860 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q8WUH2; gene symbol TGFBRAP1.
- Organism: Homo sapiens.
- Length: 860 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, body mass index and body fat percentage.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transforming growth factor-beta receptor-associated protein 1 |
|---|---|
| UniProt accession | Q8WUH2 |
| Gene | TGFBRAP1 |
| Organism | Homo sapiens |
| Length | 860 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.30
- body mass index · score 0.29
- body fat percentage · score 0.26
- age at menarche · score 0.24
- smoking status measurement · score 0.24
- schizophrenia · score 0.19
- intelligence · score 0.19
- mathematical ability · score 0.19
- age at first sexual intercourse measurement · score 0.19
- antisocial behaviour measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WUH2-F1 | alphafold | PREDICTED | 87.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WUH2.
Amino-acid sequence (860 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TGFBRAP1?
The strongest Open Targets associations for TGFBRAP1 are self reported educational attainment, body mass index, body fat percentage, age at menarche and smoking status measurement.
How long is the TGFBRAP1 protein?
The Homo sapiens TGFBRAP1 protein (UniProt Q8WUH2) is 860 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WUH2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WUH2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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