Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1)
Homo sapiens — UniProt Q8WUK0
Data last refreshed: (UniProt release unknown)
Key facts
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1) is a protein from Homo sapiens identified by UniProt accession Q8WUK0, 201 residues long. MolForge cross-references it against 1 known binders and 87 disease associations.
- UniProt accession: Q8WUK0; gene symbol PTPMT1.
- Organism: Homo sapiens.
- Length: 201 amino acids.
- Approved drugs acting on it (DrugCentral): Alexidine.
- Top disease associations (Open Targets): neurodegenerative disease, pulse pressure measurement and diastolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 |
|---|---|
| UniProt accession | Q8WUK0 |
| Gene | PTPMT1 |
| Organism | Homo sapiens |
| Length | 201 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (87)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- pulse pressure measurement · score 0.27
- diastolic blood pressure · score 0.26
- reticulocyte count · score 0.24
- systolic blood pressure · score 0.23
- aspartate aminotransferase measurement · score 0.20
- heel bone mineral density · score 0.18
- serum alanine aminotransferase measurement · score 0.16
- triglyceride measurement · score 0.16
- lymphocyte count · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WUK0-F1 | alphafold | PREDICTED | 91.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WUK0.
Amino-acid sequence (201 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target PTPMT1?
DrugCentral lists 1 approved drug whose mechanism of action is PTPMT1: Alexidine.
Which diseases are associated with PTPMT1?
The strongest Open Targets associations for PTPMT1 are neurodegenerative disease, pulse pressure measurement, diastolic blood pressure, reticulocyte count and systolic blood pressure.
How long is the PTPMT1 protein?
The Homo sapiens PTPMT1 protein (UniProt Q8WUK0) is 201 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WUK0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WUK0 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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