Nuclear pore complex protein Nup133 (NUP133)
Homo sapiens — UniProt Q8WUM0
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear pore complex protein Nup133 (NUP133) is a protein from Homo sapiens identified by UniProt accession Q8WUM0, 1156 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q8WUM0; gene symbol NUP133.
- Organism: Homo sapiens.
- Length: 1156 amino acids.
- Top disease associations (Open Targets): nephrotic syndrome, Galloway-Mowat syndrome and influenza.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear pore complex protein Nup133 |
|---|---|
| UniProt accession | Q8WUM0 |
| Gene | NUP133 |
| Organism | Homo sapiens |
| Length | 1156 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- nephrotic syndrome · score 0.66
- Galloway-Mowat syndrome · score 0.56
- influenza · score 0.54
- HIV infection · score 0.54
- viral disease · score 0.53
- COVID-19 · score 0.37
- Histiocytosis · score 0.37
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.37
- clear cell renal carcinoma · score 0.28
- pancreatic adenocarcinoma · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WUM0-F1 | alphafold | PREDICTED | 78.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WUM0.
Amino-acid sequence (1156 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NUP133?
The strongest Open Targets associations for NUP133 are nephrotic syndrome, Galloway-Mowat syndrome, influenza, HIV infection and viral disease.
How long is the NUP133 protein?
The Homo sapiens NUP133 protein (UniProt Q8WUM0) is 1156 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WUM0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WUM0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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