Protein BRICK1 (BRK1)
Homo sapiens — UniProt Q8WUW1
Data last refreshed: (UniProt release unknown)
Key facts
Protein BRICK1 (BRK1) is a protein from Homo sapiens identified by UniProt accession Q8WUW1, 75 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q8WUW1; gene symbol BRK1.
- Organism: Homo sapiens.
- Length: 75 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, breast adenocarcinoma and endometrial cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein BRICK1 |
|---|---|
| UniProt accession | Q8WUW1 |
| Gene | BRK1 |
| Organism | Homo sapiens |
| Length | 75 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- breast adenocarcinoma · score 0.25
- endometrial cancer · score 0.18
- body mass index · score 0.13
- lean body mass · score 0.11
- head and neck squamous cell carcinoma · score 0.11
- fat body mass · score 0.09
- BMI-adjusted hip circumference · score 0.04
- body height · score 0.03
- body fat percentage · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WUW1-F1 | alphafold | PREDICTED | 93.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WUW1.
Amino-acid sequence (75 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BRK1?
The strongest Open Targets associations for BRK1 are neurodegenerative disease, breast adenocarcinoma, endometrial cancer, body mass index and lean body mass.
How long is the BRK1 protein?
The Homo sapiens BRK1 protein (UniProt Q8WUW1) is 75 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WUW1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WUW1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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