Complexin-3 (CPLX3)
Homo sapiens — UniProt Q8WVH0
Data last refreshed: (UniProt release unknown)
Key facts
Complexin-3 (CPLX3) is a protein from Homo sapiens identified by UniProt accession Q8WVH0, 158 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q8WVH0; gene symbol CPLX3.
- Organism: Homo sapiens.
- Length: 158 amino acids.
- Top disease associations (Open Targets): platelet component distribution width, systolic blood pressure and diastolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Complexin-3 |
|---|---|
| UniProt accession | Q8WVH0 |
| Gene | CPLX3 |
| Organism | Homo sapiens |
| Length | 158 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- platelet component distribution width · score 0.10
- systolic blood pressure · score 0.09
- diastolic blood pressure · score 0.09
- alcohol consumption measurement · score 0.08
- smoking status measurement · score 0.08
- low density lipoprotein cholesterol measurement · score 0.07
- mean arterial pressure · score 0.07
- alcohol drinking · score 0.06
- monocyte count · score 0.06
- celiac disease · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WVH0-F1 | alphafold | PREDICTED | 74.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WVH0.
Amino-acid sequence (158 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CPLX3?
The strongest Open Targets associations for CPLX3 are platelet component distribution width, systolic blood pressure, diastolic blood pressure, alcohol consumption measurement and smoking status measurement.
How long is the CPLX3 protein?
The Homo sapiens CPLX3 protein (UniProt Q8WVH0) is 158 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WVH0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WVH0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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