Twist-related protein 2 (TWIST2)
Homo sapiens — UniProt Q8WVJ9
Data last refreshed: (UniProt release unknown)
Key facts
Twist-related protein 2 (TWIST2) is a protein from Homo sapiens identified by UniProt accession Q8WVJ9, 160 residues long. MolForge cross-references it against 0 known binders and 253 disease associations.
- UniProt accession: Q8WVJ9; gene symbol TWIST2.
- Organism: Homo sapiens.
- Length: 160 amino acids.
- Top disease associations (Open Targets): focal facial dermal dysplasia type III, Barber-Say syndrome and ablepharon macrostomia syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Twist-related protein 2 |
|---|---|
| UniProt accession | Q8WVJ9 |
| Gene | TWIST2 |
| Organism | Homo sapiens |
| Length | 160 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (253)
Diseases linked to this target (Open Targets).
- focal facial dermal dysplasia type III · score 0.68
- Barber-Say syndrome · score 0.67
- ablepharon macrostomia syndrome · score 0.67
- focal facial dermal dysplasia type II · score 0.47
- focal facial dermal dysplasia · score 0.45
- body height · score 0.42
- hair shape measurement · score 0.41
- balding measurement · score 0.40
- chronic obstructive pulmonary disease · score 0.40
- genetic disorder · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WVJ9-F1 | alphafold | PREDICTED | 73.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WVJ9.
Amino-acid sequence (160 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TWIST2?
The strongest Open Targets associations for TWIST2 are focal facial dermal dysplasia type III, Barber-Say syndrome, ablepharon macrostomia syndrome, focal facial dermal dysplasia type II and focal facial dermal dysplasia.
How long is the TWIST2 protein?
The Homo sapiens TWIST2 protein (UniProt Q8WVJ9) is 160 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WVJ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WVJ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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