U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (SNRNP27)
Homo sapiens — UniProt Q8WVK2
Data last refreshed: (UniProt release unknown)
Key facts
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (SNRNP27) is a protein from Homo sapiens identified by UniProt accession Q8WVK2, 155 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q8WVK2; gene symbol SNRNP27.
- Organism: Homo sapiens.
- Length: 155 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, platelet count and chronotype measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein |
|---|---|
| UniProt accession | Q8WVK2 |
| Gene | SNRNP27 |
| Organism | Homo sapiens |
| Length | 155 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- platelet count · score 0.20
- chronotype measurement · score 0.16
- mean platelet volume · score 0.15
- atrial fibrillation · score 0.13
- Red cell distribution width · score 0.13
- reticulocyte count · score 0.11
- reticulocyte measurement · score 0.10
- platelet component distribution width · score 0.08
- platelet crit · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WVK2-F1 | alphafold | PREDICTED | 59.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WVK2.
Amino-acid sequence (155 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNRNP27?
The strongest Open Targets associations for SNRNP27 are neurodegenerative disease, platelet count, chronotype measurement, mean platelet volume and atrial fibrillation.
How long is the SNRNP27 protein?
The Homo sapiens SNRNP27 protein (UniProt Q8WVK2) is 155 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WVK2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WVK2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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