Spindle and kinetochore-associated protein 2 (SKA2)
Homo sapiens — UniProt Q8WVK7
Data last refreshed: (UniProt release unknown)
Key facts
Spindle and kinetochore-associated protein 2 (SKA2) is a protein from Homo sapiens identified by UniProt accession Q8WVK7, 121 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.
- UniProt accession: Q8WVK7; gene symbol SKA2.
- Organism: Homo sapiens.
- Length: 121 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, breast cancer and renal cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spindle and kinetochore-associated protein 2 |
|---|---|
| UniProt accession | Q8WVK7 |
| Gene | SKA2 |
| Organism | Homo sapiens |
| Length | 121 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (81)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.24
- breast cancer · score 0.08
- renal cell carcinoma · score 0.07
- diastolic blood pressure · score 0.07
- mean reticulocyte volume · score 0.06
- esophageal squamous cell carcinoma · score 0.06
- mean corpuscular volume · score 0.05
- myeloperoxidase measurement · score 0.05
- drug use measurement · score 0.04
- sitosterolemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WVK7-F1 | alphafold | PREDICTED | 88.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WVK7.
Amino-acid sequence (121 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SKA2?
The strongest Open Targets associations for SKA2 are neurodegenerative disease, breast cancer, renal cell carcinoma, diastolic blood pressure and mean reticulocyte volume.
How long is the SKA2 protein?
The Homo sapiens SKA2 protein (UniProt Q8WVK7) is 121 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WVK7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WVK7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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