Limb region 1 protein homolog (LMBR1)
Homo sapiens — UniProt Q8WVP7
Data last refreshed: (UniProt release unknown)
Key facts
Limb region 1 protein homolog (LMBR1) is a protein from Homo sapiens identified by UniProt accession Q8WVP7, 490 residues long. MolForge cross-references it against 0 known binders and 235 disease associations.
- UniProt accession: Q8WVP7; gene symbol LMBR1.
- Organism: Homo sapiens.
- Length: 490 amino acids.
- Top disease associations (Open Targets): polydactyly of a triphalangeal thumb, laurin-Sandrow syndrome and tibia, hypoplasia or aplasia of, with polydactyly.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Limb region 1 protein homolog |
|---|---|
| UniProt accession | Q8WVP7 |
| Gene | LMBR1 |
| Organism | Homo sapiens |
| Length | 490 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (235)
Diseases linked to this target (Open Targets).
- polydactyly of a triphalangeal thumb · score 0.77
- laurin-Sandrow syndrome · score 0.72
- tibia, hypoplasia or aplasia of, with polydactyly · score 0.69
- triphalangeal thumb-polysyndactyly syndrome · score 0.69
- syndactyly type 4 · score 0.66
- Triphalangeal thumb - polysyndactyly syndrome · score 0.65
- acheiropody · score 0.62
- preaxial polydactyly of fingers · score 0.53
- Acheiropodia · score 0.47
- Absent tibia - polydactyly · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WVP7-F1 | alphafold | PREDICTED | 79.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WVP7.
Amino-acid sequence (490 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LMBR1?
The strongest Open Targets associations for LMBR1 are polydactyly of a triphalangeal thumb, laurin-Sandrow syndrome, tibia, hypoplasia or aplasia of, with polydactyly, triphalangeal thumb-polysyndactyly syndrome and syndactyly type 4.
How long is the LMBR1 protein?
The Homo sapiens LMBR1 protein (UniProt Q8WVP7) is 490 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WVP7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WVP7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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