Protein POF1B (POF1B)
Homo sapiens — UniProt Q8WVV4
Data last refreshed: (UniProt release unknown)
Key facts
Protein POF1B (POF1B) is a protein from Homo sapiens identified by UniProt accession Q8WVV4, 589 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.
- UniProt accession: Q8WVV4; gene symbol POF1B.
- Organism: Homo sapiens.
- Length: 589 amino acids.
- Top disease associations (Open Targets): primary ovarian insufficiency, Varicose veins and vein disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein POF1B |
|---|---|
| UniProt accession | Q8WVV4 |
| Gene | POF1B |
| Organism | Homo sapiens |
| Length | 589 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (35)
Diseases linked to this target (Open Targets).
- primary ovarian insufficiency · score 0.50
- Varicose veins · score 0.33
- vein disorder · score 0.33
- lymphatic system disease · score 0.33
- Premature ovarian insufficiency · score 0.21
- premature menopause · score 0.19
- breast carcinoma · score 0.04
- cholestasis, progressive familial intrahepatic, 7, with or without hearing loss · score 0.03
- blue diaper syndrome · score 0.03
- lung carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WVV4-F1 | alphafold | PREDICTED | 61.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WVV4.
Amino-acid sequence (589 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POF1B?
The strongest Open Targets associations for POF1B are primary ovarian insufficiency, Varicose veins, vein disorder, lymphatic system disease and Premature ovarian insufficiency.
How long is the POF1B protein?
The Homo sapiens POF1B protein (UniProt Q8WVV4) is 589 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WVV4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WVV4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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