E3 ubiquitin-protein ligase RNF133 (RNF133)
Homo sapiens — UniProt Q8WVZ7
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF133 (RNF133) is a protein from Homo sapiens identified by UniProt accession Q8WVZ7, 376 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q8WVZ7; gene symbol RNF133.
- Organism: Homo sapiens.
- Length: 376 amino acids.
- Top disease associations (Open Targets): MODY, 3-hydroxy-3-methylglutaryl-CoA synthase deficiency and hyperproinsulinemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF133 |
|---|---|
| UniProt accession | Q8WVZ7 |
| Gene | RNF133 |
| Organism | Homo sapiens |
| Length | 376 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- MODY · score 0.05
- 3-hydroxy-3-methylglutaryl-CoA synthase deficiency · score 0.05
- hyperproinsulinemia · score 0.04
- age at menarche · score 0.04
- exercise-induced hyperinsulinism · score 0.04
- glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.04
- Glycogen storage disease due to hepatic glycogen synthase deficiency · score 0.04
- hyperinsulinism due to INSR deficiency · score 0.03
- Systemic lupus erythematosus · score 0.01
- Infertility · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WVZ7-F1 | alphafold | PREDICTED | 77.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WVZ7.
Amino-acid sequence (376 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF133?
The strongest Open Targets associations for RNF133 are MODY, 3-hydroxy-3-methylglutaryl-CoA synthase deficiency, hyperproinsulinemia, age at menarche and exercise-induced hyperinsulinism.
How long is the RNF133 protein?
The Homo sapiens RNF133 protein (UniProt Q8WVZ7) is 376 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WVZ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WVZ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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