Na(+)/dicarboxylate cotransporter 3 (SLC13A3)
Homo sapiens — UniProt Q8WWT9
Data last refreshed: (UniProt release unknown)
Key facts
Na(+)/dicarboxylate cotransporter 3 (SLC13A3) is a protein from Homo sapiens identified by UniProt accession Q8WWT9, 602 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.
- UniProt accession: Q8WWT9; gene symbol SLC13A3.
- Organism: Homo sapiens.
- Length: 602 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate, neurodegenerative disease and serum metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Na(+)/dicarboxylate cotransporter 3 |
|---|---|
| UniProt accession | Q8WWT9 |
| Gene | SLC13A3 |
| Organism | Homo sapiens |
| Length | 602 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (72)
Diseases linked to this target (Open Targets).
- leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate · score 0.59
- neurodegenerative disease · score 0.42
- serum metabolite measurement · score 0.39
- neuroinflammatory disorder · score 0.36
- brain measurement · score 0.30
- chronic kidney disease · score 0.29
- glomerular filtration rate · score 0.28
- Parkinson disease · score 0.21
- Alzheimer disease · score 0.21
- lysosomal storage disease · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WWT9-F1 | alphafold | PREDICTED | 81.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WWT9.
Amino-acid sequence (602 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC13A3?
The strongest Open Targets associations for SLC13A3 are leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate, neurodegenerative disease, serum metabolite measurement, neuroinflammatory disorder and brain measurement.
How long is the SLC13A3 protein?
The Homo sapiens SLC13A3 protein (UniProt Q8WWT9) is 602 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WWT9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WWT9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.