Oncoprotein-induced transcript 3 protein (OIT3)
Homo sapiens — UniProt Q8WWZ8
Data last refreshed: (UniProt release unknown)
Key facts
Oncoprotein-induced transcript 3 protein (OIT3) is a protein from Homo sapiens identified by UniProt accession Q8WWZ8, 545 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.
- UniProt accession: Q8WWZ8; gene symbol OIT3.
- Organism: Homo sapiens.
- Length: 545 amino acids.
- Top disease associations (Open Targets): total cholesterol measurement, triglyceride measurement and HMG CoA reductase inhibitor use measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Oncoprotein-induced transcript 3 protein |
|---|---|
| UniProt accession | Q8WWZ8 |
| Gene | OIT3 |
| Organism | Homo sapiens |
| Length | 545 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (91)
Diseases linked to this target (Open Targets).
- total cholesterol measurement · score 0.41
- triglyceride measurement · score 0.41
- HMG CoA reductase inhibitor use measurement · score 0.33
- low density lipoprotein cholesterol measurement · score 0.30
- coronary artery disease · score 0.29
- neurodegenerative disease · score 0.27
- sex hormone-binding globulin measurement · score 0.22
- serum gamma-glutamyl transferase measurement · score 0.16
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WWZ8-F1 | alphafold | PREDICTED | 78.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WWZ8.
Amino-acid sequence (545 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with OIT3?
The strongest Open Targets associations for OIT3 are total cholesterol measurement, triglyceride measurement, HMG CoA reductase inhibitor use measurement, low density lipoprotein cholesterol measurement and coronary artery disease.
How long is the OIT3 protein?
The Homo sapiens OIT3 protein (UniProt Q8WWZ8) is 545 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WWZ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WWZ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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