RUN and FYVE domain-containing protein 2 (RUFY2)
Homo sapiens — UniProt Q8WXA3
Data last refreshed: (UniProt release unknown)
Key facts
RUN and FYVE domain-containing protein 2 (RUFY2) is a protein from Homo sapiens identified by UniProt accession Q8WXA3, 606 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q8WXA3; gene symbol RUFY2.
- Organism: Homo sapiens.
- Length: 606 amino acids.
- Top disease associations (Open Targets): HbA1c measurement, body height and MODY.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RUN and FYVE domain-containing protein 2 |
|---|---|
| UniProt accession | Q8WXA3 |
| Gene | RUFY2 |
| Organism | Homo sapiens |
| Length | 606 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- HbA1c measurement · score 0.37
- body height · score 0.16
- MODY · score 0.11
- appendicular lean mass · score 0.09
- type 2 diabetes mellitus · score 0.08
- type 1 diabetes mellitus · score 0.07
- diabetes mellitus, transient neonatal, 2 · score 0.07
- body weight · score 0.05
- hyperinsulinism due to glucokinase deficiency · score 0.05
- osteosarcoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXA3-F1 | alphafold | PREDICTED | 81.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXA3.
Amino-acid sequence (606 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RUFY2?
The strongest Open Targets associations for RUFY2 are HbA1c measurement, body height, MODY, appendicular lean mass and type 2 diabetes mellitus.
How long is the RUFY2 protein?
The Homo sapiens RUFY2 protein (UniProt Q8WXA3) is 606 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXA3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXA3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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