5-hydroxytryptamine receptor 3C (HTR3C)
Homo sapiens — UniProt Q8WXA8
Data last refreshed: (UniProt release unknown)
Key facts
5-hydroxytryptamine receptor 3C (HTR3C) is a protein from Homo sapiens identified by UniProt accession Q8WXA8, 447 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q8WXA8; gene symbol HTR3C.
- Organism: Homo sapiens.
- Length: 447 amino acids.
- Top disease associations (Open Targets): schizophrenia, post operative nausea and vomiting and irritable bowel syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 5-hydroxytryptamine receptor 3C |
|---|---|
| UniProt accession | Q8WXA8 |
| Gene | HTR3C |
| Organism | Homo sapiens |
| Length | 447 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.59
- post operative nausea and vomiting · score 0.57
- irritable bowel syndrome · score 0.54
- schizoaffective disorder · score 0.50
- type 2 diabetes mellitus · score 0.46
- psychosis · score 0.46
- Nausea and vomiting · score 0.46
- cancer · score 0.44
- Chemotherapy-induced nausea and vomiting · score 0.44
- Vomiting · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXA8-F1 | alphafold | PREDICTED | 80.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXA8.
Amino-acid sequence (447 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HTR3C?
The strongest Open Targets associations for HTR3C are schizophrenia, post operative nausea and vomiting, irritable bowel syndrome, schizoaffective disorder and type 2 diabetes mellitus.
How long is the HTR3C protein?
The Homo sapiens HTR3C protein (UniProt Q8WXA8) is 447 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXA8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXA8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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