Splicing regulatory glutamine/lysine-rich protein 1 (SREK1)
Homo sapiens — UniProt Q8WXA9
Data last refreshed: (UniProt release unknown)
Key facts
Splicing regulatory glutamine/lysine-rich protein 1 (SREK1) is a protein from Homo sapiens identified by UniProt accession Q8WXA9, 508 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q8WXA9; gene symbol SREK1.
- Organism: Homo sapiens.
- Length: 508 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and urate measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Splicing regulatory glutamine/lysine-rich protein 1 |
|---|---|
| UniProt accession | Q8WXA9 |
| Gene | SREK1 |
| Organism | Homo sapiens |
| Length | 508 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- lysosomal storage disease · score 0.36
- urate measurement · score 0.23
- bone density · score 0.23
- multisite chronic pain · score 0.21
- Alzheimer disease · score 0.17
- Parkinson disease · score 0.17
- multiple sclerosis · score 0.17
- systolic blood pressure · score 0.16
- PHF-tau measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXA9-F1 | alphafold | PREDICTED | 63.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXA9.
Amino-acid sequence (508 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SREK1?
The strongest Open Targets associations for SREK1 are neurodegenerative disease, lysosomal storage disease, urate measurement, bone density and multisite chronic pain.
How long is the SREK1 protein?
The Homo sapiens SREK1 protein (UniProt Q8WXA9) is 508 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXA9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXA9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.