Protein N-lysine methyltransferase METTL21A (METTL21A)
Homo sapiens — UniProt Q8WXB1
Data last refreshed: (UniProt release unknown)
Key facts
Protein N-lysine methyltransferase METTL21A (METTL21A) is a protein from Homo sapiens identified by UniProt accession Q8WXB1, 218 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q8WXB1; gene symbol METTL21A.
- Organism: Homo sapiens.
- Length: 218 amino acids.
- Top disease associations (Open Targets): systolic blood pressure, mean corpuscular hemoglobin concentration and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein N-lysine methyltransferase METTL21A |
|---|---|
| UniProt accession | Q8WXB1 |
| Gene | METTL21A |
| Organism | Homo sapiens |
| Length | 218 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.38
- mean corpuscular hemoglobin concentration · score 0.37
- platelet count · score 0.37
- mean corpuscular hemoglobin · score 0.30
- alkaline phosphatase measurement · score 0.30
- mean corpuscular volume · score 0.29
- Red cell distribution width · score 0.25
- sex hormone-binding globulin measurement · score 0.25
- lean body mass · score 0.23
- mean arterial pressure · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXB1-F1 | alphafold | PREDICTED | 91.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXB1.
Amino-acid sequence (218 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with METTL21A?
The strongest Open Targets associations for METTL21A are systolic blood pressure, mean corpuscular hemoglobin concentration, platelet count, mean corpuscular hemoglobin and alkaline phosphatase measurement.
How long is the METTL21A protein?
The Homo sapiens METTL21A protein (UniProt Q8WXB1) is 218 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXB1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXB1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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