Relaxin receptor 2 (RXFP2)
Homo sapiens — UniProt Q8WXD0
Data last refreshed: (UniProt release unknown)
Key facts
Relaxin receptor 2 (RXFP2) is a protein from Homo sapiens identified by UniProt accession Q8WXD0, 754 residues long. MolForge cross-references it against 0 known binders and 196 disease associations.
- UniProt accession: Q8WXD0; gene symbol RXFP2.
- Organism: Homo sapiens.
- Length: 754 amino acids.
- Top disease associations (Open Targets): cryptorchidism, hypertension and heart failure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Relaxin receptor 2 |
|---|---|
| UniProt accession | Q8WXD0 |
| Gene | RXFP2 |
| Organism | Homo sapiens |
| Length | 754 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (196)
Diseases linked to this target (Open Targets).
- cryptorchidism · score 0.58
- hypertension · score 0.41
- heart failure · score 0.37
- systolic blood pressure · score 0.35
- Calcium channel blocker use measurement · score 0.35
- Diuretic use measurement · score 0.34
- Agents acting on the renin-angiotensin system use measurement · score 0.34
- Inguinal hernia · score 0.34
- cardiovascular disease · score 0.34
- hemoglobin measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXD0-F1 | alphafold | PREDICTED | 81.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXD0.
Amino-acid sequence (754 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RXFP2?
The strongest Open Targets associations for RXFP2 are cryptorchidism, hypertension, heart failure, systolic blood pressure and Calcium channel blocker use measurement.
How long is the RXFP2 protein?
The Homo sapiens RXFP2 protein (UniProt Q8WXD0) is 754 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXD0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXD0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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