Caskin-1 (CASKIN1)
Homo sapiens — UniProt Q8WXD9
Data last refreshed: (UniProt release unknown)
Key facts
Caskin-1 (CASKIN1) is a protein from Homo sapiens identified by UniProt accession Q8WXD9, 1431 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q8WXD9; gene symbol CASKIN1.
- Organism: Homo sapiens.
- Length: 1431 amino acids.
- Top disease associations (Open Targets): body height, fat body mass and forced expiratory volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Caskin-1 |
|---|---|
| UniProt accession | Q8WXD9 |
| Gene | CASKIN1 |
| Organism | Homo sapiens |
| Length | 1431 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- body height · score 0.11
- fat body mass · score 0.10
- forced expiratory volume · score 0.06
- behavioral variant of frontotemporal dementia · score 0.05
- hepatocellular carcinoma · score 0.05
- alkaline phosphatase measurement · score 0.04
- childhood disintegrative disorder · score 0.04
- uncombable hair syndrome · score 0.04
- Pick disease · score 0.04
- non-small cell lung carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXD9-F1 | alphafold | PREDICTED | 53.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXD9.
Amino-acid sequence (1431 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CASKIN1?
The strongest Open Targets associations for CASKIN1 are body height, fat body mass, forced expiratory volume, behavioral variant of frontotemporal dementia and hepatocellular carcinoma.
How long is the CASKIN1 protein?
The Homo sapiens CASKIN1 protein (UniProt Q8WXD9) is 1431 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXD9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXD9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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