Caskin-2 (CASKIN2)
Homo sapiens — UniProt Q8WXE0
Data last refreshed: (UniProt release unknown)
Key facts
Caskin-2 (CASKIN2) is a protein from Homo sapiens identified by UniProt accession Q8WXE0, 1202 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q8WXE0; gene symbol CASKIN2.
- Organism: Homo sapiens.
- Length: 1202 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, serum gamma-glutamyl transferase measurement and PR interval.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Caskin-2 |
|---|---|
| UniProt accession | Q8WXE0 |
| Gene | CASKIN2 |
| Organism | Homo sapiens |
| Length | 1202 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- serum gamma-glutamyl transferase measurement · score 0.23
- PR interval · score 0.20
- platelet count · score 0.14
- forced expiratory volume · score 0.12
- FEV/FVC ratio · score 0.12
- erythrocyte count · score 0.11
- calcium measurement · score 0.11
- serum alanine aminotransferase measurement · score 0.09
- vital capacity · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXE0-F1 | alphafold | PREDICTED | 57.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXE0.
Amino-acid sequence (1202 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CASKIN2?
The strongest Open Targets associations for CASKIN2 are neurodegenerative disease, serum gamma-glutamyl transferase measurement, PR interval, platelet count and forced expiratory volume.
How long is the CASKIN2 protein?
The Homo sapiens CASKIN2 protein (UniProt Q8WXE0) is 1202 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXE0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXE0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.