ATR-interacting protein (ATRIP)
Homo sapiens — UniProt Q8WXE1
Data last refreshed: (UniProt release unknown)
Key facts
ATR-interacting protein (ATRIP) is a protein from Homo sapiens identified by UniProt accession Q8WXE1, 791 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.
- UniProt accession: Q8WXE1; gene symbol ATRIP.
- Organism: Homo sapiens.
- Length: 791 amino acids.
- Top disease associations (Open Targets): Aicardi-Goutieres syndrome 1, Hereditary vascular retinopathy and retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATR-interacting protein |
|---|---|
| UniProt accession | Q8WXE1 |
| Gene | ATRIP |
| Organism | Homo sapiens |
| Length | 791 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- Aicardi-Goutieres syndrome 1 · score 0.57
- Hereditary vascular retinopathy · score 0.57
- retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations · score 0.57
- HERNS syndrome · score 0.57
- Cerebroretinal vasculopathy · score 0.57
- chilblain lupus 1 · score 0.57
- systemic lupus erythematosus · score 0.48
- Seckel syndrome · score 0.46
- chilblain lupus · score 0.42
- genetic disorder · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8WXE1-F1 | alphafold | PREDICTED | 68.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8WXE1.
Amino-acid sequence (791 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ATRIP?
The strongest Open Targets associations for ATRIP are Aicardi-Goutieres syndrome 1, Hereditary vascular retinopathy, retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations, HERNS syndrome and Cerebroretinal vasculopathy.
How long is the ATRIP protein?
The Homo sapiens ATRIP protein (UniProt Q8WXE1) is 791 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8WXE1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8WXE1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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